Translational research in cancer immunotherapy and the tumor microenvironment

We study how immune cells, cancer cells, stromal programs, multi-omics signals, and clinical data can be connected to improve biomarker discovery and immunotherapy decisions.

Explore research Review paper candidates

Research Focus

Six connected directions, one translational question

The lab links tumor biology, immune response, computational analysis, and clinical evidence into practical research systems.

Clinical Cohorts

Prospective cohorts under construction

Immunotherapy multi-omics cohort

A planned 2,000-patient cohort centered on metagenomics and metabolomics to study immune therapy response, resistance, toxicity, and host-microbiome-metabolism interactions.

Scientific questions: Which microbiome-metabolite patterns predict immunotherapy benefit or toxicity? Can microbial functions explain primary resistance and acquired resistance? Which signals are stable enough for prospective stratification?

Pathology and imaging cohorts

Multi-cancer pathology and imaging cohorts designed to connect tissue morphology, radiological phenotypes, clinical outcomes, and computational oncology models.

Scientific questions: Can pathology and radiology jointly identify immune-hot or immune-cold tumors? Which visual features predict recurrence, metastasis, response, and drug resistance? How can image models remain explainable in clinical oncology?

Pan-cancer single-cell and spatial cohorts

Self-generated pan-cancer single-cell and spatial transcriptomics cohorts, expected to reach 1,000+ and 300+ patients respectively, for immune ecology and spatial mechanism studies.

Scientific questions: Which cell states drive immune escape and metastasis across cancers? How do CAFs, macrophages, T cells, and tumor cells organize spatial niches? Which spatial programs can become drug targets or companion diagnostics?

Faculty members and clinical researchers interested in these cohorts are warmly welcome to contact us for collaboration.

Email the lab

Resources

Web tools and database-driven research

Open the dedicated subpage for detailed project descriptions.

Publication Candidates

Papers grouped by research direction

Review 10 candidate papers for each research direction before final selection.

Contact

RobinL Lab

Zhujiang Hospital, Southern Medical University

luopeng@smu.edu.cn ResearchGate

Visitors

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